Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.41 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.35 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL27466382 | 0.98 | MAPT (0.43) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Methacrylic Acid SCHEMBL25248517 | 0.96 | MAPT (0.42) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Hydrochloric Acid SCHEMBL28025200 | 0.86 | TDP1 (0.48) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Acetic Acid SCHEMBL28210362 | 0.84 | MAPT (0.50) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Methacrylic Acid SCHEMBL6678142 | 0.83 | SLC22A16 (0.47) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Bicarbonate SCHEMBL28323258 | 0.82 | MAPT (0.52) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Methacrylic Acid SCHEMBL29064100 | 0.82 | SLC22A16 (0.45) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Acetic Acid SCHEMBL11505398 | 0.80 | SLC22A16 (0.52) | MAPTSMN1; SMN2BLMGALR3CHRM1 | |
| Hydrochloric Acid SCHEMBL9748760 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL9748547 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6287701-B1 | BLEND OF WATER SOLUBLE RESIN, ORGANOSILICON COMPOUND AND WATER | CHUO RIKA KOGYO CORPORATION (JP) | 2001-09-11 | — | — | US | disclosed |