Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 14/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 6/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976688 | 0.83 | EGFR (0.67) | EGFRKDRPIK3CAPIK3CGFLT1 | |
| SCHEMBL7966427 | 0.77 | EGFR (0.61) | EGFRKDRPIK3CAPIK3CGFLT1 | |
| SCHEMBL5554543 | 0.76 | EGFR (0.64) | EGFRKDRPIK3CAPIK3CGFLT1 | |
| SCHEMBL8976304 | 0.74 | EGFR (0.71) | EGFRKDRPIK3CAPIK3CGFLT1 | |
| SCHEMBL3606262 | 0.73 | EGFR (0.73) | EGFRKDRPIK3CAPIK3CGFLT1 | |
| Hydrochloric Acid SCHEMBL8976476 | 0.73 | EGFR (0.70) | EGFRKDRPIK3CAPIK3CGFLT1 | |
| Hydrochloric Acid SCHEMBL8593958 | 0.72 | EGFR (0.72) | EGFRKDRFLT1 | |
| Hydrochloric Acid SCHEMBL4386000 | 0.72 | RET (0.67) | EGFRKDRFLT1ERBB2RET | |
| SCHEMBL8093519 | 0.71 | EGFR (1.00) | EGFRPIK3CAPIK3CGFLT1ERBB2 | |
| SCHEMBL1733829 | 0.71 | EGFR (0.76) | EGFRKDRPIK3CAPIK3CGFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6225318-B1 | 4-aminoquinazolone derivatives | PFIZER INC | 2001-05-01 | — | — | US | disclosed |
| EP-0837063-A1 | 4-Aminoquinazoline derivatives | PFIZER INC. (US) | 1998-04-22 | — | — | EP | disclosed |