Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 6/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976688 | 0.84 | EGFR (0.67) | EGFRPIK3CAPIK3CGERBB2FLT1 | |
| SCHEMBL7966427 | 0.80 | EGFR (0.61) | EGFRPIK3CAPIK3CGERBB2FLT1 | |
| SCHEMBL8093519 | 0.78 | EGFR (1.00) | EGFRPIK3CAPIK3CGERBB2FLT1 | |
| SCHEMBL1733829 | 0.77 | EGFR (0.76) | EGFRPIK3CAPIK3CGERBB2FLT1 | |
| SCHEMBL5553169 | 0.76 | EGFR (0.63) | EGFRPIK3CAPIK3CGERBB2 | |
| SCHEMBL5549473 | 0.76 | EGFR (0.63) | EGFRERBB2KDR | |
| SCHEMBL8976304 | 0.76 | EGFR (0.71) | EGFRPIK3CAPIK3CGERBB2FLT1 | |
| SCHEMBL7979941 | 0.76 | EGFR (0.54) | EGFRPIK3CAPIK3CGERBB2FLT1 | |
| SCHEMBL1022178 | 0.75 | IMPDH2 (0.53) | MAP3K14 | |
| SCHEMBL7124503 | 0.75 | EGFR (0.71) | EGFRPIK3CAPIK3CGERBB2FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147093-B1 | SUBSTITUTED BICYCLIC DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2007-04-11 | — | — | EP | disclosed |