Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334859 | 0.74 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL6781345 | 0.71 | — | — | |
| SCHEMBL25840018 | 0.69 | PTGS2 (0.51) | PTGS2PTGS1HTR7MAPTMCL1 | |
| SCHEMBL10304874 | 0.68 | PTGS2 (0.44) | PTGS2PTGS1HTR7 | |
| SCHEMBL27496672 | 0.68 | PTGS2 (0.41) | PTGS2PTGS1HTR7MAPTLMNA | |
| SCHEMBL9306464 | 0.68 | PTGS2 (0.47) | PTGS2PTGS1NOTUMMAPTMCL1 | |
| SCHEMBL19912967 | 0.67 | PTGS2 (0.50) | PTGS2PTGS1MCL1 | |
| SCHEMBL5917278 | 0.67 | — | — | |
| SCHEMBL21374024 | 0.67 | PTGS2 (0.46) | PTGS2PTGS1HTR7 | |
| SCHEMBL21374025 | 0.67 | PTGS2 (0.40) | PTGS2PTGS1HTR7MAPTMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001027119-A2 | SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | disclosed |