Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980055 | 0.74 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL28445344 | 0.70 | PTGS2 (0.43) | PTGS2PTGS1EPHB4NISCHTDP2 | |
| SCHEMBL1275684 | 0.70 | PTGS2 (0.35) | PTGS2PTGS1KMOAHR | |
| SCHEMBL27707582 | 0.70 | PTGS2 (0.43) | PTGS2PTGS1EPHB4NISCHTDP2 | |
| SCHEMBL14880521 | 0.70 | CTSL (0.34) | — | |
| SCHEMBL6781345 | 0.70 | — | — | |
| SCHEMBL31067152 | 0.68 | PTGS2 (0.58) | PTGS2PTGS1EPHB4NISCHADORA2A | |
| SCHEMBL20898128 | 0.68 | PTGS2 (0.58) | PTGS2PTGS1EPHB4NISCHADORA2A | |
| SCHEMBL694819 | 0.67 | PTGS2 (0.43) | PTGS2PTGS1EPHB4NISCHTDP2 | |
| SCHEMBL8210186 | 0.67 | RPA1 (0.40) | PTGS2PTGS1EPHB4NISCHTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2533645-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2012-12-19 | — | — | EP | disclosed |
| WO-2011100373-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |