Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | NMT2 | O60551 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.36 |
| ▸ | TLR2 | O60603 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12264542 | 1.00 | SIRT6 (0.43) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| SCHEMBL25556371 | 0.94 | MMP1 (0.40) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| SCHEMBL26630660 | 0.86 | SIRT6 (0.42) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| SCHEMBL14414403 | 0.86 | MMP1 (0.43) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| SCHEMBL21944205 | 0.86 | SIRT6 (0.47) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| SCHEMBL20366275 | 0.85 | GABRR1 (0.38) | MMP1MMP3DPP8DPP9DPP7 | |
| SCHEMBL10442144 | 0.85 | GABRR1 (0.38) | MMP1MMP3DPP8DPP9DPP7 | |
| SCHEMBL20705272 | 0.83 | SIRT6 (0.47) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| SCHEMBL13555546 | 0.83 | SIRT6 (0.40) | SIRT6SIRT1FOLH1MMP1MMP3 | |
| SCHEMBL13331678 | 0.83 | SIRT6 (0.61) | SIRT6SIRT1FOLH1MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3076175-A1 | DETECTION AND QUANTIFICATION OF O-ACETYL-ADP-RIBOSE AS A READOUT SYSTEM FOR MEASURING THE ACTIVITY OF E.G. SIRTUINS | Boehringer Ingelheim International GmbH (DE) | 2016-10-05 | — | — | EP | disclosed |
| WO-2011161545-A2 | NON-HYDROLYZABLE PROTEIN CONJUGATES, METHODS AND COMPOSITIONS RELATED THERETO | THE NETHERLANDS CANCER INSTITUTE (NL) | 2011-12-29 | — | — | WO | disclosed |
| US-6281352-B1 | ANTIINFLAMMATORY AGENTS | DUPONT PHARMACEUTICALS COMPANY | 2001-08-28 | — | — | US | disclosed |