Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986529 | 0.91 | KDR (0.44) | KDRMAPTFLT1KITFLT4 | |
| SCHEMBL7969458 | 0.91 | KDR (0.46) | KDRMAPTFLT1KITFLT4 | |
| SCHEMBL7980109 | 0.90 | KDR (0.44) | KDRMAPTFLT1KITFLT4 | |
| SCHEMBL7982719 | 0.89 | KDR (0.53) | KDRMAPTFLT1FLT4NPC1 | |
| SCHEMBL7969516 | 0.86 | KDR (0.44) | KDRMAPTFLT1KITFLT4 | |
| SCHEMBL7979634 | 0.86 | MEN1 (0.45) | KDRMAPTFLT1FLT4KDM4E | |
| SCHEMBL7746570 | 0.81 | KDR (0.49) | KDRFLT1KITFLT4KDM4E | |
| SCHEMBL7982851 | 0.80 | KDR (0.52) | KDRMAPTFLT1FLT4KDM4E | |
| SCHEMBL7969519 | 0.80 | KDR (0.44) | KDRMAPTFLT1KITFLT4 | |
| SCHEMBL7979692 | 0.79 | KDR (0.54) | KDRFLT1FLT4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |