Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | ADCY1 | Q08828 | 5/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986016 | 0.91 | KDR (0.46) | KDRFLT1KITHTTSMN1; SMN2 | |
| SCHEMBL7969458 | 0.91 | KDR (0.46) | KDRFLT1KITSMN1; SMN2TDP1 | |
| SCHEMBL7980109 | 0.88 | KDR (0.44) | KDRFLT1KITHTTSMN1; SMN2 | |
| SCHEMBL7982851 | 0.88 | KDR (0.52) | KDRFLT1HPGDMAPK14FLT4 | |
| SCHEMBL7969516 | 0.86 | KDR (0.44) | KDRFLT1KITSMN1; SMN2CYP1A2 | |
| SCHEMBL7746570 | 0.81 | KDR (0.49) | KDRFLT1KITSMN1; SMN2POLB | |
| SCHEMBL7969519 | 0.80 | KDR (0.44) | KDRFLT1KITSMN1; SMN2CYP1A2 | |
| SCHEMBL7982719 | 0.79 | KDR (0.53) | KDRFLT1POLBFLT4KMT2A | |
| SCHEMBL7979692 | 0.77 | KDR (0.54) | KDRFLT1FLT4RAB9ANPC1 | |
| SCHEMBL7981592 | 0.77 | ADCY1 (0.45) | ADCY1HTTSMN1; SMN2TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |