SCHEMBL7980342

SCHEMBL7980342

CCC(C)(C)C(=O)C(=O)N1Cc2ccccc2C[C@H]1C(=O)OCCC(c1ccccc1)c1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FKBP1A P62942 19/20 0.69
NR1D1 P20393 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7980344 1.00 FKBP1A (0.69) FKBP1ANR1D1
SCHEMBL7253232 0.84 FKBP1A (0.88) FKBP1A
SCHEMBL7978726 0.83 FKBP1A (0.64) FKBP1A
SCHEMBL7978725 0.83 FKBP1A (0.64) FKBP1A
SCHEMBL8796618 0.82 FKBP1A (0.96) FKBP1A
SCHEMBL7246458 0.81 FKBP1A (0.71) FKBP1A
SCHEMBL7980422 0.81 ACE (0.54) FKBP1A
SCHEMBL7983145 0.81 ACE (0.54) FKBP1A
SCHEMBL7761776 0.79 FKBP1A (0.68) FKBP1A
SCHEMBL7982576 0.78 FKBP1A (0.68) FKBP1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323215-B1 TREAT AND PREVENT DISORDERS CHARACTERIZED BY NEURONAL DAMAGE SUCH AS PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, STROKE, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS, DIABETIC NEUROPATHY AND BELL'S PALSY. ORTHO-MCNEIL PHARMACEUTICAL, INC. 2001-11-27 US disclosed