Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983145 | 1.00 | ACE (0.54) | ACEPOLBTDP1L3MBTL1FKBP1A | |
| SCHEMBL7980051 | 0.83 | OPRM1 (0.55) | POLBTDP1FKBP1A | |
| SCHEMBL7979966 | 0.81 | ACE (0.46) | ACEFKBP1A | |
| SCHEMBL7980342 | 0.81 | FKBP1A (0.69) | FKBP1A | |
| SCHEMBL7980344 | 0.81 | FKBP1A (0.69) | FKBP1A | |
| SCHEMBL26748805 | 0.80 | ACE (0.57) | ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL14397408 | 0.79 | ACE (0.59) | ACEPOLBTDP1L3MBTL1 | |
| SCHEMBL7978726 | 0.77 | FKBP1A (0.64) | FKBP1A | |
| SCHEMBL7978725 | 0.77 | FKBP1A (0.64) | FKBP1A | |
| SCHEMBL4113622 | 0.76 | ACE (0.66) | ACEPOLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323215-B1 | TREAT AND PREVENT DISORDERS CHARACTERIZED BY NEURONAL DAMAGE SUCH AS PARKINSON'S DISEASE, ALZHEIMER'S DISEASE, STROKE, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS, DIABETIC NEUROPATHY AND BELL'S PALSY. | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2001-11-27 | — | — | US | disclosed |