Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7977358 | 0.68 | TSHR (0.32) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL7977027 | 0.66 | RAB9A (0.35) | SMN1; SMN2ALDH1A1MAPK1NPC1GAA | |
| SCHEMBL29423714 | 0.60 | ALDH1A1 (0.31) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL167247 | 0.60 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1MAPK1KDM4ENPC1 | |
| SCHEMBL6801673 | 0.58 | DRD4 (0.45) | SMN1; SMN2ALDH1A1KDM4EGAA | |
| SCHEMBL16161354 | 0.57 | HSD17B10 (0.37) | SMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL14502277 | 0.57 | ALDH1A1 (0.36) | SMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL289021 | 0.57 | — | — | |
| SCHEMBL581560 | 0.57 | MAPK1 (0.32) | MAPK1KDM4E | |
| SCHEMBL30375516 | 0.57 | MAPK1 (0.32) | MAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6174909-B1 | FOR TREATING ANALGESIA, PSYCHOSIS, CONVULSIONS, EPILEPSY, ANXIETY, MUSCULAR AND MOVEMENT DISORDERS, SPASTIC DISORDERS OR SYMPTOMS OF HUNTINGTON'S OR PARKINSONS DISEASE | H. LUNDBECK A/S (DK) | 2001-01-16 | — | — | US | disclosed |
| US-5998613-A | PSYCHOLOGICAL DISORDERS; ANALGESICS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 1999-12-07 | — | — | US | disclosed |
| EP-0812318-A1 | 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1997-12-17 | — | — | EP | disclosed |
| WO-1996026929-A1 | 4-AMINOTETRAHYDROBENZISOXAZOLE OR -ISOTHIAZOLE COMPOUNDS | H. LUNDBECK A/S (DK) | 1996-09-06 | — | — | WO | disclosed |