Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980620 | 0.91 | LCK (0.38) | LCKHSP90AA1HSP90AB1GABRA5GABRG2 | |
| SCHEMBL31177679 | 0.78 | GABRA5 (0.56) | LCKGABRA5FGFR1GABRA1KDM4E | |
| SCHEMBL31137466 | 0.72 | LCK (0.58) | LCKBRD4 | |
| SCHEMBL29892956 | 0.70 | PARP1 (0.52) | LCKFGFR1KDM4EGAAHTR7 | |
| SCHEMBL7980590 | 0.70 | PARP1 (0.52) | LCKFGFR1KDM4EGAAHTR7 | |
| SCHEMBL7214732 | 0.70 | PARP1 (0.45) | KDM4EGAA | |
| SCHEMBL31026820 | 0.70 | PARP1 (0.49) | LCKFGFR1KDM4EGAAMAPT | |
| SCHEMBL7436018 | 0.70 | B3GNT2 (0.47) | GABRG2GABRB3GABRA1GABRA2KDM4E | |
| SCHEMBL31136945 | 0.69 | LCK (0.64) | LCKBRD4 | |
| SCHEMBL16064638 | 0.69 | CNR2 (0.47) | GABRA5GABRG2GABRB3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |