SCHEMBL7214732

SCHEMBL7214732

COC(=O)c1ccc2c(c1)[nH]c(=O)n2C(=O)OC(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 3/20 0.45
KIF11 P52732 2/20 0.45
KDM4E B2RXH2 5/20 0.45
ALDH1A1 P00352 5/20 0.45
HPGD P15428 3/20 0.45
HSD17B10 Q99714 3/20 0.45
GAA P10253 2/20 0.45
HTT P42858 2/20 0.45
KMT2A Q03164 2/20 0.45
PKM P14618 2/20 0.45
GLA P06280 1/20 0.45
RAB9A P51151 2/20 0.44
NPC1 O15118 1/20 0.41
CREBBP Q92793 1/20 0.41
CSNK2A1 P68400 1/20 0.41
LMNA P02545 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
MEN1 O00255 1/20 0.40
B3GNT2 Q9NY97 1/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7436018 0.90 B3GNT2 (0.47) PARP1KIF11KDM4EALDH1A1HPGD
SCHEMBL25275524 0.82 DAO (0.54) B3GNT2POLB
SCHEMBL640969 0.81 GABRG2 (0.48) B3GNT2
SCHEMBL318223 0.81 LMNA (0.45) KMT2ALMNAL3MBTL1MEN1
SCHEMBL4296595 0.81 CDK1 (0.46) DYRK1A
SCHEMBL21464105 0.81 DAO (0.52) KMT2AMEN1
SCHEMBL4950092 0.79 KCNQ3 (0.42) KIF11KDM4EGAAKMT2A
SCHEMBL4947575 0.79 MAPT (0.50) KIF11ALDH1A1KMT2AMEN1
SCHEMBL10202230 0.79 DAO (0.35) B3GNT2
SCHEMBL29848320 0.78 HSD11B1 (0.51) ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9359350-B2 Ring-fused compound SATO PHARMACEUTICAL CO., LTD. (JP) 2016-06-07 US disclosed
US-20150203490-A1 RING-FUSED COMPOUND SATO PHARMACEUTICAL CO., LTD. (JP) 2015-07-23 US disclosed
US-8987473-B2 Ring-fused compound SATO PHARMACEUTICAL CO., LTD. (JP) 2015-03-24 US disclosed
WO-2012102405-A1 RING-FUSED COMPOUND 佐藤製薬株式会社 (JP) 2012-08-02 WO disclosed
US-6534535-B1 Administering indole derivative as anticoagulant MILLENNIUM PHARMACEUTICALS, INC. 2003-03-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150203490-A1 RING-FUSED COMPOUND URB2, RCOR1, RCC2 PARP1 4198/4885KIF11 4243/4885KDM4E 2113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.