Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7986674 | 0.91 | KDR (0.45) | KDRFLT1FLT4KDM4EMAPT | |
| SCHEMBL7981622 | 0.89 | KDR (0.44) | KDRFLT1FLT4KDM4ESMN1; SMN2 | |
| SCHEMBL7979634 | 0.88 | MEN1 (0.45) | KDRFLT1FLT4KDM4ESMN1; SMN2 | |
| SCHEMBL7979899 | 0.88 | KDR (0.52) | KDRFLT1FLT4KDM4ESMN1; SMN2 | |
| SCHEMBL7982719 | 0.85 | KDR (0.53) | KDRFLT1FLT4MAPTKMT2A | |
| SCHEMBL7979621 | 0.81 | KDR (0.50) | KDRFLT1FLT4KDM4ESMN1; SMN2 | |
| SCHEMBL7744200 | 0.80 | KDR (0.53) | KDRFLT1FLT4KDM4EMAPT | |
| SCHEMBL7981592 | 0.79 | ADCY1 (0.45) | KDM4ESMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL7982881 | 0.78 | ADCY1 (0.50) | KDRKDM4ESMN1; SMN2MAPTMEN1 | |
| SCHEMBL7982851 | 0.76 | KDR (0.52) | KDRFLT1FLT4KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |