Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | UTRN | P46939 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980770 | 0.88 | KDR (0.46) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7986674 | 0.87 | KDR (0.45) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7979692 | 0.86 | KDR (0.54) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7981622 | 0.85 | KDR (0.44) | KDRFLT1FLT4NPC1MEN1 | |
| SCHEMBL7982616 | 0.83 | KDR (0.56) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7744200 | 0.80 | KDR (0.53) | KDRFLT1FLT4NPC1MEN1 | |
| SCHEMBL7979897 | 0.79 | KDR (0.47) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7979634 | 0.79 | MEN1 (0.45) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7979682 | 0.78 | KDR (0.46) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7982881 | 0.78 | ADCY1 (0.50) | KDRNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |