Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981592 | 0.91 | ADCY1 (0.45) | MEN1KMT2AADCY1MAPTKDM4E | |
| SCHEMBL7982881 | 0.90 | ADCY1 (0.50) | MEN1KMT2AADCY1MAPTKDM4E | |
| SCHEMBL7980770 | 0.88 | KDR (0.46) | MEN1KMT2AMAPTCYP3A4CYP2C19 | |
| SCHEMBL7986016 | 0.86 | KDR (0.46) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7744781 | 0.81 | ADCY1 (0.47) | MEN1KMT2AADCY1MAPTCYP3A4 | |
| SCHEMBL7981622 | 0.80 | KDR (0.44) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7986674 | 0.80 | KDR (0.45) | MEN1KMT2AMAPTCYP2C19CYP1A2 | |
| SCHEMBL7979899 | 0.79 | KDR (0.52) | MEN1KMT2AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL7986529 | 0.77 | KDR (0.44) | MEN1KMT2AADCY1MAPTCYP3A4 | |
| SCHEMBL7969458 | 0.77 | KDR (0.46) | MEN1KMT2AMAPTCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |