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SCHEMBL7981100

SCHEMBL7981100

COc1cc2c(nc(N)c3cncn32)c(-c2c(F)cccc2Cl)c1NCCN(C)C

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ LCK P06239 17/20 0.58
▸ EED O75530 1/20 0.36
▸ SUZ12 Q15022 1/20 0.36
▸ EZH2 Q15910 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ CSF1R P07333 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7983111 0.92 LCK (0.58) LCK
SCHEMBL7980036 0.84 LCK (0.54) LCKSMN1; SMN2CSF1R
SCHEMBL7979832 0.83 LCK (0.49) LCK
SCHEMBL7987033 0.78 LCK (0.49) LCK
SCHEMBL7982995 0.77 LCK (0.47) LCK
SCHEMBL7987540 0.77 LCK (0.46) LCK
SCHEMBL7979958 0.77 LCK (0.56) LCK
SCHEMBL7984582 0.76 LCK (0.61) LCKSMN1; SMN2
SCHEMBL7982713 0.75 LCK (0.51) LCK
SCHEMBL4042263 0.71 LCK (0.47) LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6235740-B1 AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS BRISTOL-MYERS SQUIBB CO. 2001-05-22 — — US claimed
WO-1999009845-A1 IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 1999-03-04 — — WO claimed
US-6235740-B1 AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS BRISTOL-MYERS SQUIBB CO. 2001-05-22 — — US disclosed