Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.54 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982930 | 0.97 | LCK (0.51) | LCKWEE1FGFR1KDRDRD3 | |
| SCHEMBL7983214 | 0.96 | LCK (0.51) | LCKWEE1FGFR1KDRDRD3 | |
| SCHEMBL7982709 | 0.95 | LCK (0.53) | LCKWEE1FGFR1KDRPIK3CD | |
| SCHEMBL7987014 | 0.91 | LCK (0.45) | LCKWEE1FGFR1KDRSRC | |
| SCHEMBL7979955 | 0.87 | LCK (0.54) | LCKFGFR1KDR | |
| SCHEMBL7987029 | 0.86 | LCK (0.45) | LCKWEE1FGFR1KDRMAP4K4 | |
| SCHEMBL7983693 | 0.86 | LCK (0.43) | LCKFGFR1KDRSRC | |
| SCHEMBL7983879 | 0.84 | FGFR1 (0.55) | LCKFGFR1KDRSRC | |
| SCHEMBL7982991 | 0.83 | LCK (0.43) | LCKWEE1FGFR1KDRMAP4K4 | |
| SCHEMBL7987537 | 0.83 | LCK (0.42) | LCKWEE1FGFR1KDRMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |