Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.45 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 6/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982991 | 0.97 | LCK (0.43) | LCKWEE1PDE2AFGFR1KDR | |
| SCHEMBL7987537 | 0.97 | LCK (0.42) | LCKWEE1PDE2AFGFR1KDR | |
| SCHEMBL7979828 | 0.95 | LCK (0.48) | LCKPDE2AFGFR1KDRPDE10A | |
| SCHEMBL7979955 | 0.88 | LCK (0.54) | LCKPDE2AFGFR1KDR | |
| SCHEMBL7981128 | 0.86 | LCK (0.54) | LCKWEE1FGFR1KDRMAP4K4 | |
| SCHEMBL7983672 | 0.85 | FGFR1 (0.53) | LCKFGFR1KDR | |
| SCHEMBL7982930 | 0.83 | LCK (0.51) | LCKWEE1PDE2AFGFR1KDR | |
| SCHEMBL7969691 | 0.83 | NPC1 (0.39) | LCKPDE2ACDK9PDE10A | |
| SCHEMBL7983214 | 0.83 | LCK (0.51) | LCKWEE1FGFR1KDRCDK9 | |
| SCHEMBL7980015 | 0.83 | LCK (0.52) | LCKPDE2AFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |