Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | PDE2A | O00408 | 6/20 | 0.38 |
| ▸ | CDK9 | P50750 | 2/20 | 0.38 |
| ▸ | WEE1 | P30291 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987537 | 0.99 | LCK (0.42) | LCKFGFR1KDRPDE2ACDK9 | |
| SCHEMBL7987029 | 0.97 | LCK (0.45) | LCKFGFR1KDRPDE2ACDK9 | |
| SCHEMBL7979828 | 0.94 | LCK (0.48) | LCKFGFR1KDRPDE2APDE10A | |
| SCHEMBL7979955 | 0.87 | LCK (0.54) | LCKFGFR1KDRPDE2A | |
| SCHEMBL7982930 | 0.86 | LCK (0.51) | LCKFGFR1KDRPDE2ACDK9 | |
| SCHEMBL7983214 | 0.85 | LCK (0.51) | LCKFGFR1KDRCDK9WEE1 | |
| SCHEMBL7983672 | 0.84 | FGFR1 (0.53) | LCKFGFR1KDRSRC | |
| SCHEMBL7981128 | 0.83 | LCK (0.54) | LCKFGFR1KDRWEE1MAP4K4 | |
| SCHEMBL7969691 | 0.82 | NPC1 (0.39) | LCKPDE2ACDK9CCNT1PDE10A | |
| SCHEMBL7980015 | 0.82 | LCK (0.52) | LCKFGFR1KDRPDE2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |