Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053698 | 0.82 | SCN2A (0.42) | NR1H2NR1H3MEN1KMT2AKDM4E | |
| SCHEMBL7444304 | 0.77 | GRM5 (0.46) | NR1H2NR1H3MEN1KMT2AGAA | |
| SCHEMBL26092414 | 0.74 | NPC1 (0.43) | MEN1KMT2AKDM4ELMNAHPGD | |
| SCHEMBL8316943 | 0.72 | GABRA1 (0.39) | MEN1KMT2AKDM4EGAACYP3A4 | |
| SCHEMBL9781279 | 0.71 | GRM7 (0.34) | ESR1ESR2KDM4EGAAGLA | |
| SCHEMBL1053052 | 0.69 | XDH (0.42) | MEN1KMT2AKDM4EGAACYP3A4 | |
| SCHEMBL29829217 | 0.68 | GABRA1 (0.48) | MEN1KMT2AKDM4EGAALMNA | |
| SCHEMBL13978658 | 0.68 | GABRA1 (0.48) | MEN1KMT2AKDM4EGAALMNA | |
| SCHEMBL13321963 | 0.67 | KDM4E (0.40) | ESR1ESR2KDM4EGAAALDH1A1 | |
| SCHEMBL9812589 | 0.67 | GABRA1 (0.49) | NR1H2NR1H3MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204384-B1 | THROMBIN INHIBITOR; ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. | 2001-03-20 | — | — | US | disclosed |
| US-6011047-A | Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors | CORVAS INTERNATIONAL INC. (US) | 2000-01-04 | — | — | US | disclosed |