SCHEMBL7981499

SCHEMBL7981499

COC(=O)[C@H](Cc1ccc(OS(=O)(=O)C(F)(F)F)cc1)NS(=O)(=O)c1ccc(C)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.56
CTSL P07711 1/20 0.51
MMP9 P14780 5/20 0.47
MMP2 P08253 5/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
POLB P06746 1/20 0.47
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
BMP1 P13497 2/20 0.45
ITGB3 P05106 1/20 0.45
ITGA2B P08514 1/20 0.45
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
MMP13 P45452 1/20 0.44
CA12 O43570 1/20 0.44
CA7 P43166 1/20 0.44
CA9 Q16790 1/20 0.44
CA14 Q9ULX7 1/20 0.44
ATM Q13315 1/20 0.44
EGFR P00533 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7970488 0.91 POLB (0.54) CTSLMMP9MMP2L3MBTL1POLB
SCHEMBL7983820 0.85 F2 (0.53) MMP9MMP2POLBMEN1KMT2A
SCHEMBL1504320 0.84 TDP1 (0.59) TDP1CTSLMMP9MMP2L3MBTL1
SCHEMBL12817580 0.84 CA12 (0.49) POLBMEN1KMT2AALDH1A1CA12
SCHEMBL12817578 0.84 CA12 (0.49) POLBMEN1KMT2AALDH1A1CA12
SCHEMBL20335144 0.84 CTSL (0.67) TDP1CTSLMMP9MMP2L3MBTL1
SCHEMBL8057955 0.84 TDP1 (0.62) TDP1CTSLMMP9MMP2L3MBTL1
SCHEMBL20335146 0.84 CTSL (0.67) TDP1CTSLMMP9MMP2L3MBTL1
SCHEMBL14534184 0.84 CTSL (0.67) TDP1CTSLMMP9MMP2L3MBTL1
SCHEMBL7981960 0.83 TDP1 (0.60) TDP1CTSLMMP9MMP2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6284912-B1 Process for synthesizing para-and/or meta-substituted cyanophenyalanine derivatives LG CHEMICAL, LTD. (KR) 2001-09-04 US claimed