Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | CTSL | P07711 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CTSS | P25774 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 6/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14534184 | 0.95 | CTSL (0.67) | TDP1CTSLPOLBATML3MBTL1 | |
| SCHEMBL20335144 | 0.95 | CTSL (0.67) | TDP1CTSLPOLBATML3MBTL1 | |
| SCHEMBL20335146 | 0.95 | CTSL (0.67) | TDP1CTSLPOLBATML3MBTL1 | |
| SCHEMBL27568136 | 0.92 | POLB (0.70) | CTSLPOLBMMP9MEN1KMT2A | |
| SCHEMBL26606026 | 0.91 | MMP9 (0.69) | TDP1CTSLPOLBMMP9MEN1 | |
| SCHEMBL26606022 | 0.91 | MMP9 (0.69) | TDP1CTSLPOLBMMP9MEN1 | |
| SCHEMBL13226933 | 0.90 | POLB (0.60) | CTSLPOLBATML3MBTL1MMP9 | |
| SCHEMBL7984123 | 0.90 | POLB (0.60) | CTSLPOLBL3MBTL1MMP9MEN1 | |
| SCHEMBL7981960 | 0.88 | TDP1 (0.60) | TDP1CTSLPOLBATML3MBTL1 | |
| SCHEMBL8063645 | 0.88 | TDP1 (0.78) | TDP1POLBL3MBTL1MMP9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009042092-A1 | 2-ARYL OR HETEROARYL INDOLE DERIVATIVES | MERCK & CO., INC. (US) | 2009-04-02 | — | — | WO | disclosed |