Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA6 | P23280 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369146 | 0.86 | CYP3A4 (0.62) | MAPTCYP3A4MAOAACHECA1 | |
| SCHEMBL4571013 | 0.86 | CYP3A4 (1.00) | MAPTCYP3A4KDM4EMAOAALDH1A1 | |
| SCHEMBL29394312 | 0.86 | CYP3A4 (1.00) | MAPTCYP3A4KDM4EMAOAALDH1A1 | |
| SCHEMBL2138785 | 0.86 | CYP3A4 (1.00) | MAPTCYP3A4KDM4EMAOAALDH1A1 | |
| SCHEMBL22953335 | 0.86 | CYP3A4 (1.00) | MAPTCYP3A4KDM4EMAOAALDH1A1 | |
| SCHEMBL7984438 | 0.85 | MAPT (0.56) | MAPTCYP3A4KDM4EALDH1A1ACHE | |
| SCHEMBL28642174 | 0.85 | CYP3A4 (0.56) | MAPTCYP3A4KDM4EMAOAALDH1A1 | |
| SCHEMBL25646743 | 0.84 | CYP3A4 (0.54) | MAPTCYP3A4KDM4EALDH1A1ACHE | |
| SCHEMBL16156009 | 0.81 | CYP3A4 (0.56) | MAPTCYP3A4KDM4EMAOAALDH1A1 | |
| SCHEMBL29460958 | 0.80 | CYP3A4 (0.78) | MAPTCYP3A4KDM4EMAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211226-B1 | 11-Aza prostaglandins for the treatment of glaucoma and ocular hypertension | ALCON LABORATORIES, INC. | 2001-04-03 | — | — | US | disclosed |
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |
| EP-0004291-B1 | REACTIVE MEDIUM FOR ELECTROCHROMIC DISPLAY DEVICES AND ELECTROCHROMIC DISPLAY INCLUDING SUCH REACTIVE MEDIUM | International Business Machines Corporation (US) | 1981-03-11 | — | — | EP | disclosed |
| EP-0004291-A2 | Reactive medium for electrochromic display devices and electrochromic display including such reactive medium | International Business Machines Corporation (US) | 1979-10-03 | — | — | EP | disclosed |
| US-4139276-A | Electrochromic display devices comprising substituted fluorene compounds | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1979-02-13 | — | — | US | disclosed |