Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | DRD5 | P21918 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981630 | 0.85 | MAPT (0.75) | MAPTCYP3A4DRD1DRD4DRD5 | |
| SCHEMBL28999524 | 0.83 | KDM4E (0.47) | MAPTCYP3A4DRD1DRD4DRD5 | |
| SCHEMBL25646743 | 0.83 | CYP3A4 (0.54) | MAPTCYP3A4DRD1DRD4DRD5 | |
| SCHEMBL8081751 | 0.82 | KDM4E (0.46) | MAPTCYP3A4DRD1DRD4DRD5 | |
| SCHEMBL28642174 | 0.81 | CYP3A4 (0.56) | MAPTCYP3A4DRD1DRD4DRD5 | |
| SCHEMBL3287680 | 0.81 | ALDH1A1 (0.56) | MAPTCYP3A4DRD1DRD4DRD5 | |
| SCHEMBL26217307 | 0.79 | ADORA1 (0.55) | MAPTDRD4KDM4ERAB9AMAPK1 | |
| SCHEMBL5058433 | 0.79 | SMN1; SMN2 (0.64) | MAPTCYP3A4KDM4ERAB9AMAPK1 | |
| SCHEMBL18582934 | 0.79 | SMN1; SMN2 (0.64) | MAPTCYP3A4KDM4ERAB9AMAPK1 | |
| SCHEMBL5016641 | 0.79 | SMN1; SMN2 (0.64) | MAPTCYP3A4KDM4ERAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |
| EP-0004291-B1 | REACTIVE MEDIUM FOR ELECTROCHROMIC DISPLAY DEVICES AND ELECTROCHROMIC DISPLAY INCLUDING SUCH REACTIVE MEDIUM | International Business Machines Corporation (US) | 1981-03-11 | — | — | EP | disclosed |
| EP-0004291-A2 | Reactive medium for electrochromic display devices and electrochromic display including such reactive medium | International Business Machines Corporation (US) | 1979-10-03 | — | — | EP | disclosed |
| US-4139276-A | Electrochromic display devices comprising substituted fluorene compounds | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1979-02-13 | — | — | US | disclosed |