Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744651 | 0.92 | HPGD (0.51) | KDRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7981666 | 0.88 | KDR (0.46) | KDRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7739007 | 0.85 | KDR (0.51) | KDRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7744758 | 0.85 | ALDH1A1 (0.46) | HPGDKDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL7739022 | 0.84 | KDR (0.54) | KDRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7969453 | 0.82 | HPGD (0.46) | KDRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7744659 | 0.80 | KDR (0.50) | KDRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7744655 | 0.79 | HPGD (0.50) | KDRHPGDKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7744790 | 0.79 | HPN (0.43) | KDRALDH1A1RAB9AHSP90AA1SMN1; SMN2 | |
| SCHEMBL7744192 | 0.78 | KDR (0.51) | KDRHPGDKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |