Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969453 | 0.89 | HPGD (0.46) | KDRHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7981663 | 0.88 | KDR (0.50) | KDRHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7744655 | 0.81 | HPGD (0.50) | KDRHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7744651 | 0.80 | HPGD (0.51) | KDRHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7979621 | 0.77 | KDR (0.50) | KDRALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL7744758 | 0.76 | ALDH1A1 (0.46) | HPGDALDH1A1KDM4EHSD17B10RAB9A | |
| SCHEMBL7980821 | 0.76 | KDR (0.54) | KDRRAB9ANPC1CYP1A2MAPT | |
| SCHEMBL7983601 | 0.76 | KDR (0.53) | KDRRAB9ANPC1CYP1A2MAPT | |
| SCHEMBL7739007 | 0.75 | KDR (0.51) | KDRHPGDALDH1A1KDM4EHSD17B10 | |
| SCHEMBL7739010 | 0.75 | KDR (0.47) | KDRHPGDALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |