Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7986131 | 0.99 | CACNA1I (0.42) | CACNA1IKCNH2TP53MAPTSMN1; SMN2 | |
| SCHEMBL7985752 | 0.95 | CACNA1I (0.44) | CACNA1IKCNH2TP53MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7984545 | 0.94 | CACNA1I (0.43) | CACNA1IKCNH2TP53MAPTSMN1; SMN2 | |
| SCHEMBL7972913 | 0.92 | LTA4H (0.42) | CACNA1IKCNH2LTA4HHTR7HDAC3 | |
| Hydrochloric Acid SCHEMBL7982374 | 0.91 | KDM1A (0.41) | CACNA1IKCNH2LTA4HHTR7HDAC3 | |
| SCHEMBL7982426 | 0.91 | LTA4H (0.47) | KCNH2GSK3BLTA4HHDAC3HDAC4 | |
| SCHEMBL7983503 | 0.91 | KDM1A (0.42) | ACHEGSK3BLTA4HHTR7 | |
| Hydrochloric Acid SCHEMBL7971795 | 0.90 | LTA4H (0.47) | KCNH2GSK3BLTA4HHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL7981947 | 0.90 | KDM1A (0.41) | ACHEGSK3BLTA4HHTR7 | |
| SCHEMBL7989635 | 0.89 | LTA4H (0.45) | GSK3BLTA4HHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235731-B1 | REDUCING BLOOD LIPIDS, SUGARS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0915888-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | Takeda Chemical Industries, Ltd. (JP) | 1999-05-19 | — | — | EP | disclosed |
| WO-1997040051-A1 | FUSED IMIDAZOPYRIDINE DERIVATIVES AS ANTIHYPERLIPIDEMIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |