Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.52 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL478989 | 0.89 | LMNA (0.59) | MEN1KMT2ACACNA1BAPBA1HTT | |
| SCHEMBL20606513 | 0.83 | EGFR (0.59) | POLBKDM4EALDH1A1HPGD | |
| SCHEMBL20606528 | 0.83 | HTT (0.57) | MEN1KMT2ACACNA1BAPBA1POLB | |
| SCHEMBL16833090 | 0.83 | MEN1 (0.55) | MEN1KMT2ACACNA1BAPBA1POLB | |
| SCHEMBL20460325 | 0.82 | ALOX15 (0.63) | OPRM1TMEM97SIGMAR1 | |
| SCHEMBL18736526 | 0.81 | HDAC1 (0.50) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL20606393 | 0.80 | SMN1; SMN2 (0.54) | MEN1KMT2AMAPTKDM4EHSD17B10 | |
| SCHEMBL31497721 | 0.77 | SMN1; SMN2 (0.60) | MEN1KMT2APOLBRAB9AHTT | |
| SCHEMBL11114138 | 0.76 | P2RY12 (0.46) | MEN1KMT2ACACNA1BAPBA1POLB | |
| SCHEMBL2546886 | 0.76 | RAB9A (0.52) | MEN1KMT2APOLBRAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003475-A2 | NOVEL PYRROLIDONE DERIVATIVES FOR USE AS METAP-2 INHIBITORS | MERCK PATENT GMBH (DE) | 2010-01-14 | — | — | WO | disclosed |
| EP-0107938-A1 | Quinoline or hydroquinoline compounds, their preparation and pharmaceutical compostions comprising them | KOWA COMPANY, LTD. (JP) | 1984-05-09 | — | — | EP | disclosed |