Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7737905 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2POLBALDH1A1LMNACYP1A2 | |
| SCHEMBL6816712 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2POLBALDH1A1LMNACYP1A2 | |
| SCHEMBL6811708 | 0.82 | ALDH1A1 (0.47) | SMN1; SMN2POLBALDH1A1LMNACYP1A2 | |
| SCHEMBL4059419 | 0.77 | SMN1; SMN2 (0.42) | SMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL9932241 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBALDH1A1LMNACYP1A2 | |
| SCHEMBL9932242 | 0.75 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBALDH1A1LMNACYP1A2 | |
| SCHEMBL6819377 | 0.74 | KMT2A (0.53) | SMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL6814634 | 0.73 | NPC1 (0.51) | SMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL6815982 | 0.73 | NPC1 (0.51) | SMN1; SMN2POLBALDH1A1LMNA | |
| SCHEMBL6068054 | 0.71 | LMNA (0.54) | SMN1; SMN2POLBALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271236-B1 | PHENYL UREAS/THIOUREAS AS INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE ENZYME, USEFUL IN TREATING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, AND VARICELLA-ZOSTER VIRUS | WYETH | 2001-08-07 | — | — | US | disclosed |