Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165271 | 0.88 | — | — | |
| SCHEMBL29504479 | 0.88 | — | — | |
| Urea SCHEMBL1760920 | 0.78 | PI4KA (0.36) | PI4KAPI4K2BPI4K2API4KB | |
| Phosphoric Acid SCHEMBL9933547 | 0.78 | FDPS (0.39) | PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL28957900 | 0.75 | PI4KA (0.31) | PI4KAPI4K2BPI4K2API4KB | |
| Acetamide SCHEMBL9933914 | 0.75 | PI4KA (0.34) | PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL655393 | 0.73 | — | — | |
| Piperazine SCHEMBL798343 | 0.70 | HTR2C (0.44) | HTR2C | |
| SCHEMBL31049795 | 0.70 | — | — | |
| SCHEMBL30770352 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616077-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035423-A1 | ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES | KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) | 2012-03-22 | — | — | WO | disclosed |