Phosphoric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ADRB3 CYP11B1 DPP4 FGFR1 FGFR2 FGFR3 FGFR4 HRH1 JAK1 JAK2 JAK3 KCNA1 KCNA10 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNB1 KCNB2 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ2 KCNQ3 KCNQ4 KCNQ5 KCNS1 KCNS2 KCNS3 KCNV1 KCNV2 KDR KIT NA OPRD1 OPRK1 OPRM1 P PDGFRB PIK3CD SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SMO TYK2 pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	FDPS	P14324	1/20	0.39

▸	PI4KA	P42356	1/20	0.32

▸	PI4K2B	Q8TCG2	1/20	0.32

▸	PI4K2A	Q9BTU6	1/20	0.32

▸	PI4KB	Q9UBF8	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Urea SCHEMBL1760920	0.85	PI4KA (0.36)	PI4KAPI4K2BPI4K2API4KB
SCHEMBL655393	0.73	—	—
SCHEMBL31049795	0.70	—	—
SCHEMBL1602375	0.67	EGFR (0.34)	—
Phosphoric Acid SCHEMBL28981554	0.65	FDPS (0.37)	FDPS
Purine SCHEMBL595228	0.63	KDM4A (0.36)	FDPS
SCHEMBL11302336	0.59	CA2 (0.42)	FDPS
SCHEMBL127479	0.59	EGFR (0.50)	FDPS
SCHEMBL374791	0.57	—	—
SCHEMBL27541625	0.57	HCAR2 (0.39)	—

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2655377-B1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS	GLENMARK PHARMACEUTICALS SA (CH)	2016-03-30	—	—	EP	disclosed
US-9073955-B2	2-amino-4-arylthiazole compounds as TRPA1 antagonists	GLENMARK PHARMACEUTICALS, S.A. (CH)	2015-07-07	—	—	US	disclosed
US-8889862-B2	2-amino-4-arylthiazole compounds as TRPA1 antagonists	GLENMARK PHARMACEUTICALS, S.A. (CH)	2014-11-18	—	—	US	disclosed
US-20140051667-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS	GLENMARK PHARMACEUTICALS, S.A. (CH)	2014-02-20	—	—	US	disclosed
US-20140045865-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS	GLENMARK PHARMACEUTICALS, S.A. (CH)	2014-02-13	—	—	US	disclosed
US-8592398-B2	2-amino-4-arylthiazole compounds as TRPA1 antagonists	GLENMARK PHARMACEUTICALS, S.A. (CH)	2013-11-26	—	—	US	disclosed
EP-2655377-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS	Glenmark Pharmaceuticals S.A. (CH)	2013-10-30	—	—	EP	disclosed
WO-2012085662-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS	GLENMARK PHARMACEUTICALS S.A. (CH)	2012-06-28	—	—	WO	disclosed
US-20120157411-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPAI ANTAGONISTS	GLENMARK PHARMACEUTICALS, S.A. (CH)	2012-06-21	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20120157411-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPAI ANTAGONISTS	TRPA1, TRPV1, TRPV2	FDPS 3674/4885PI4KA 1620/4885PI4K2B 2410/4885
US-20140045865-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS	TRPA1, TRPV1, TRPV2	FDPS 3726/4885PI4KA 2295/4885PI4K2B 2632/4885
US-20140051667-A1	2-AMINO-4-ARYLTHIAZOLE COMPOUNDS AS TRPA1 ANTAGONISTS	TRPA1, TRPV1, TRPV2	FDPS 3726/4885PI4KA 2295/4885PI4K2B 2632/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.