Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744769 | 0.91 | KDR (0.53) | KDRFLT1FLT4ADORA2AADORA1 | |
| SCHEMBL7986526 | 0.89 | KDR (0.42) | KDRFLT1FLT4ADORA3ADORA2A | |
| SCHEMBL7982717 | 0.88 | KDR (0.44) | KDRFLT1FLT4ADORA3ALOX15 | |
| SCHEMBL7739072 | 0.87 | KDR (0.43) | KDRFLT1FLT4NQO2 | |
| SCHEMBL7981120 | 0.86 | KDR (0.47) | KDRFLT1FLT4ALOX15 | |
| SCHEMBL7980279 | 0.85 | KDR (0.47) | KDRFLT1FLT4ADORA3 | |
| SCHEMBL7986670 | 0.82 | KDR (0.50) | KDRFLT1FLT4ADORA3ADORA2A | |
| SCHEMBL7746568 | 0.82 | KDR (0.41) | KDRFLT1FLT4 | |
| SCHEMBL7979682 | 0.80 | KDR (0.46) | KDRFLT1FLT4ALOX15 | |
| SCHEMBL7969457 | 0.79 | KDR (0.42) | KDRFLT1FLT4ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |