Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | ADCY1 | Q08828 | 5/20 | 0.37 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7746568 | 0.93 | KDR (0.41) | KDRFLT1FLT4ADCY1ADCY8 | |
| SCHEMBL7969457 | 0.90 | KDR (0.42) | KDRFLT1FLT4KMT2AHPGD | |
| SCHEMBL7982846 | 0.89 | KDR (0.49) | KDRFLT1FLT4ADORA3ADORA2A | |
| SCHEMBL7986013 | 0.89 | KDR (0.39) | KDRFLT1FLT4KMT2AHPGD | |
| SCHEMBL7739003 | 0.88 | HPN (0.44) | KDRFLT1FLT4KMT2ARAB9A | |
| SCHEMBL7969509 | 0.87 | MCL1 (0.38) | KDRFLT1FLT4KMT2AHPGD | |
| SCHEMBL7980106 | 0.86 | KDR (0.42) | KDRFLT1FLT4KMT2AHPGD | |
| SCHEMBL7744769 | 0.84 | KDR (0.53) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7744069 | 0.79 | KDR (0.40) | KDRFLT1FLT4HPGDNPC1 | |
| SCHEMBL7982717 | 0.77 | KDR (0.44) | KDRFLT1FLT4KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |