Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7744196 | 0.91 | KDR (0.54) | KDRFLT1FLT4ALOX15ATR | |
| SCHEMBL7980768 | 0.88 | KDR (0.45) | KDRFLT1FLT4ADORA3NPC1 | |
| SCHEMBL7744746 | 0.87 | HPN (0.45) | KDRFLT1FLT4ATRSMN1; SMN2 | |
| SCHEMBL7981618 | 0.84 | KDR (0.44) | KDRFLT1FLT4ALOX15ATR | |
| SCHEMBL7744779 | 0.82 | KDR (0.43) | KDRFLT1FLT4NPC1RAB9A | |
| SCHEMBL7982846 | 0.82 | KDR (0.49) | KDRFLT1FLT4ADORA3ADORA2A | |
| SCHEMBL7987348 | 0.80 | KDR (0.44) | KDRFLT1FLT4ADORA2AADORA1 | |
| SCHEMBL7979897 | 0.80 | KDR (0.47) | KDRFLT1FLT4HSD17B1HSD17B2 | |
| SCHEMBL7744056 | 0.79 | HPGD (0.42) | KDRFLT1FLT4ADORA3ADORA1 | |
| SCHEMBL7979629 | 0.79 | KDR (0.39) | KDRFLT1FLT4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |