Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814841 | 0.83 | MAPT (0.65) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL30608029 | 0.81 | MAPT (0.56) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL18083709 | 0.81 | CNR2 (0.49) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL7784373 | 0.80 | MAPT (0.54) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL4243563 | 0.80 | KLK1 (0.51) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL31425031 | 0.80 | TRPV1 (0.56) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL4250927 | 0.80 | ALDH1A1 (0.64) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL6816754 | 0.79 | MAPT (0.71) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL26066071 | 0.77 | LMNA (0.61) | KMT2AMEN1TDP1KCNMA1SMN1; SMN2 | |
| SCHEMBL21870338 | 0.76 | ALDH1A1 (0.64) | KMT2AMEN1TDP1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271236-B1 | PHENYL UREAS/THIOUREAS AS INHIBITORS OF INOSINE MONOPHOSPHATE DEHYDROGENASE ENZYME, USEFUL IN TREATING HUMAN CYTOMEGALOVIRUS, HERPES SIMPLEX VIRUSES, EPSTEIN-BARR VIRUS, AND VARICELLA-ZOSTER VIRUS | WYETH | 2001-08-07 | — | — | US | disclosed |