SCHEMBL798319

SCHEMBL798319

c1ccc(-c2cc3cnc(N4CCNCC4)nc3s2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 2/20 0.46
PRKCI P41743 2/20 0.46
CDK7 P50613 1/20 0.46
TAAR1 Q96RJ0 1/20 0.46
ALDH1A1 P00352 10/20 0.46
HIF1A Q16665 6/20 0.46
CYP1A2 P05177 6/20 0.46
CASP1 P29466 6/20 0.46
CASP7 P55210 6/20 0.46
HPGD P15428 6/20 0.46
HSD17B10 Q99714 5/20 0.46
CYP2C9 P11712 4/20 0.46
CYP2C19 P33261 4/20 0.46
GLA P06280 2/20 0.46
HTR1A P08908 2/20 0.46
HTR2C P28335 1/20 0.46
CYP3A4 P08684 5/20 0.45
USP2 O75604 4/20 0.45
ALOX15 P16050 1/20 0.45
KDM4E B2RXH2 4/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL798487 0.95 PRKCI (0.50) CHEK1PRKCICDK7TAAR1ALDH1A1
SCHEMBL793765 0.88 ALDH1A1 (0.45) ALDH1A1HIF1ACYP1A2CASP1CASP7
SCHEMBL656278 0.83 ALDH1A1 (0.37) CHEK1PRKCICDK7ALDH1A1HIF1A
SCHEMBL653602 0.79 ALDH1A1 (0.40) PRKCIALDH1A1HPGDHSD17B10USP2
SCHEMBL656735 0.73 IKBKB (0.44) ALDH1A1HPGDHSD17B10USP2KDM4E
SCHEMBL9400977 0.73 TAAR1 (0.64) TAAR1ALDH1A1HIF1ACYP1A2CASP1
SCHEMBL655041 0.72 USP2 (0.35) ALDH1A1HIF1ACYP1A2CASP1CASP7
SCHEMBL793832 0.71 HTR2C (0.57) TAAR1ALDH1A1HIF1ACYP1A2CASP1
SCHEMBL10219367 0.71 CHEK1 (0.56) CHEK1PRKCICDK7TAAR1HTR1A
SCHEMBL1029333 0.70 HTR3A (0.67) TAAR1ALDH1A1HIF1ACYP1A2CASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616077-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2013-07-24 EP disclosed
WO-2012035423-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2012-03-22 WO disclosed
EP-2405973-A2 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2012-01-18 EP disclosed
WO-2011147753-A1 ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) 2011-12-01 WO disclosed