SCHEMBL793765

SCHEMBL793765

Fc1ccc(-c2cc3cnc(N4CCNCC4)nc3s2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 14/20 0.45
CYP1A2 P05177 14/20 0.45
CASP1 P29466 14/20 0.45
CASP7 P55210 14/20 0.45
CYP3A4 P08684 14/20 0.45
HIF1A Q16665 13/20 0.45
USP2 O75604 12/20 0.45
CYP2C9 P11712 12/20 0.45
HSD17B10 Q99714 10/20 0.45
CYP2C19 P33261 9/20 0.45
TSHR P16473 5/20 0.45
GLA P06280 3/20 0.45
TP53 P04637 8/20 0.44
LMNA P02545 6/20 0.44
MAPK1 P28482 6/20 0.44
CYP2D6 P10635 3/20 0.44
HTR7 P34969 4/20 0.44
HTR1A P08908 3/20 0.44
RECQL P46063 1/20 0.42
BLM P54132 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL798319 0.88 CHEK1 (0.46) ALDH1A1CYP1A2CASP1CASP7CYP3A4
SCHEMBL655041 0.83 USP2 (0.35) ALDH1A1CYP1A2CASP1CASP7CYP3A4
SCHEMBL798487 0.83 PRKCI (0.50) ALDH1A1CYP1A2CASP1CASP7CYP3A4
SCHEMBL6787637 0.74 HTR7 (0.54) ALDH1A1CYP1A2CASP1CASP7CYP3A4
Hydrochloric Acid SCHEMBL20293632 0.73 HTR7 (0.52) ALDH1A1CYP1A2CASP1CASP7CYP3A4
Hydrochloric Acid SCHEMBL6786943 0.73 HTR7 (0.52) ALDH1A1CYP1A2CASP1CASP7CYP3A4
SCHEMBL655042 0.71 HRH4 (0.61) ALDH1A1HSD17B10TSHRLMNAMAPK1
SCHEMBL1694252 0.71 CYP1A2 (0.37) ALDH1A1CYP1A2CASP1CASP7CYP3A4
SCHEMBL656278 0.71 ALDH1A1 (0.37) ALDH1A1CYP1A2CASP1CASP7CYP3A4
SCHEMBL1720288 0.71 P2RY12 (0.39) ALDH1A1CYP1A2CASP1CASP7CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616077-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2013-07-24 EP disclosed
WO-2012035423-A1 ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&D (BE) 2012-03-22 WO disclosed
EP-2405973-A2 THIAZOLOPYRIMIDINE MODULATORS AS IMMUNOSUPPRESSIVE AGENTS Katholieke Universiteit Leuven, K.U. Leuven R&D (BE) 2012-01-18 EP disclosed
WO-2011147753-A1 ANTIVIRAL ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) 2011-12-01 WO disclosed
WO-2010103130-A2 NOVEL BICYCLIC HETEROCYCLES KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D (BE) 2010-09-16 WO disclosed