Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.38 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553465 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2CYP3A4CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8554094 | 0.99 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP3A4CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8109544 | 0.88 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP3A4CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8552624 | 0.82 | CYP19A1 (0.47) | SMN1; SMN2CYP3A4CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8118264 | 0.78 | DGAT2 (0.39) | CYP3A4CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL8133883 | 0.78 | CYP17A1 (0.40) | SMN1; SMN2CYP3A4CYP2D6CYP19A1CYP2C9 | |
| SCHEMBL8550969 | 0.77 | EPHX1 (0.46) | SMN1; SMN2KCNA5ADRB1ADRB3KCNH2 | |
| SCHEMBL8552459 | 0.77 | CYP17A1 (0.44) | CYP3A4CYP2D6CYP19A1CYP2C9CYP2C19 | |
| SCHEMBL8555652 | 0.77 | PPARG (0.41) | SMN1; SMN2CYP3A4CYP2C9KCNA5CYP17A1 | |
| SCHEMBL8118468 | 0.76 | KCNA5 (0.45) | CYP3A4CYP19A1KCNA5SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |