Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109544 | 0.86 | SMN1; SMN2 (0.44) | KCNA5KCNH2SMN1; SMN2CYP3A4CYP2C9 | |
| SCHEMBL8552624 | 0.83 | CYP19A1 (0.47) | KCNA5SMN1; SMN2CYP3A4CYP2C9CYP17A1 | |
| SCHEMBL8139574 | 0.83 | ALOX5AP (0.39) | KCNA5KCNH2ALOX5APFEN1SMN1; SMN2 | |
| SCHEMBL8117056 | 0.82 | CYP3A4 (0.40) | KCNA5AKR1C3AKR1C2CYP3A4MME | |
| SCHEMBL8133883 | 0.81 | CYP17A1 (0.40) | KCNA5SMN1; SMN2CYP3A4CYP2C9CYP17A1 | |
| SCHEMBL8118264 | 0.81 | DGAT2 (0.39) | KCNA5KCNH2AKR1C3AKR1C2CYP3A4 | |
| SCHEMBL8551523 | 0.81 | CYP17A1 (0.47) | SMN1; SMN2CYP3A4CYP17A1GAA | |
| SCHEMBL8552960 | 0.81 | MARS1 (0.41) | SMN1; SMN2CYP3A4NPSR1MMECYP17A1 | |
| SCHEMBL8119038 | 0.80 | CYP11B1 (0.43) | CYP3A4CYP11B1CYP11B2 | |
| SCHEMBL7772046 | 0.80 | SLC6A4 (0.42) | KCNA5SMN1; SMN2CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |