Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.58 |
| ▸ | PRKACG | P22612 | 1/20 | 0.58 |
| ▸ | PRKACB | P22694 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983836 | 0.79 | SRC (0.55) | SRCPRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL7988065 | 0.78 | SRC (0.54) | SRCPRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL7971057 | 0.77 | SRC (0.52) | SRCPRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL7970249 | 0.77 | SRC (0.57) | SRCPRKACAPRKACGPRKACBLMNA | |
| SCHEMBL7981595 | 0.76 | SRC (0.55) | SRCPRKACAPRKACGPRKACBLMNA | |
| SCHEMBL7987613 | 0.73 | SRC (1.00) | SRCPRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL7980253 | 0.70 | SRC (0.55) | SRCALDH1A1LMNATDP1MAPT | |
| SCHEMBL7970472 | 0.70 | SRC (0.55) | SRCPRKACAPRKACGPRKACBALDH1A1 | |
| SCHEMBL5072126 | 0.70 | MAPT (0.70) | ALDH1A1LMNASETD7MAPTHTT | |
| SCHEMBL27574689 | 0.69 | SMN1; SMN2 (0.62) | ALDH1A1LMNANTSR1TDP1SETD7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |