Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.57 |
| ▸ | PRKACA | P17612 | 6/20 | 0.57 |
| ▸ | PRKACG | P22612 | 6/20 | 0.57 |
| ▸ | PRKACB | P22694 | 6/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971057 | 0.85 | SRC (0.52) | SRCPRKACAPRKACGPRKACBPTGS2 | |
| SCHEMBL7987262 | 0.85 | SRC (0.50) | SRCPRKACAPRKACGPRKACBPTGS2 | |
| SCHEMBL7983836 | 0.80 | SRC (0.55) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7983604 | 0.77 | SRC (0.58) | SRCPRKACAPRKACGPRKACBLMNA | |
| SCHEMBL7980269 | 0.73 | CYP19A1 (0.43) | SMN1; SMN2 | |
| SCHEMBL7970463 | 0.73 | SRC (1.00) | SRCPRKACAPRKACGPRKACB | |
| SCHEMBL7981392 | 0.70 | SRC (0.61) | SRCPTGS2LMNAPTGS1 | |
| SCHEMBL7984223 | 0.69 | SRC (0.59) | SRCPRKACAPRKACGPRKACBLMNA | |
| SCHEMBL7970608 | 0.68 | SRC (0.50) | SRCLMNA | |
| SCHEMBL7980253 | 0.67 | SRC (0.55) | SRCPTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |