Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.55 |
| ▸ | PRKACA | P17612 | 5/20 | 0.55 |
| ▸ | PRKACG | P22612 | 5/20 | 0.55 |
| ▸ | PRKACB | P22694 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7971057 | 0.87 | SRC (0.52) | SRCPRKACAPRKACGPRKACBKMT2A | |
| SCHEMBL7988065 | 0.85 | SRC (0.54) | SRCPRKACAPRKACGPRKACBMEN1 | |
| SCHEMBL7970249 | 0.84 | SRC (0.57) | SRCPRKACAPRKACGPRKACBSMN1; SMN2 | |
| SCHEMBL7984223 | 0.84 | SRC (0.59) | SRCPRKACAPRKACGPRKACBMEN1 | |
| SCHEMBL7983836 | 0.82 | SRC (0.55) | SRCPRKACAPRKACGPRKACBMAPT | |
| SCHEMBL7983604 | 0.76 | SRC (0.58) | SRCPRKACAPRKACGPRKACBMEN1 | |
| SCHEMBL7983592 | 0.74 | SRC (0.59) | SRCPRKACAPRKACGPRKACBMAPK7 | |
| SCHEMBL7981392 | 0.71 | SRC (0.61) | SRCMEN1KMT2AMAPTLMNA | |
| SCHEMBL7970472 | 0.70 | SRC (0.55) | SRCPRKACAPRKACGPRKACBMEN1 | |
| SCHEMBL7981518 | 0.67 | P2RX4 (0.56) | SRCMEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288042-B1 | ADMINISTERING TO TREAT HUMAN T-CELL LEUKEMIA/LYMPHOMA VIRUS | ARONEX PHARMACEUTICALS, INC. | 2001-09-11 | — | — | US | claimed |
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |