Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
| ▸ | C1S | P09871 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983624 | 0.73 | HPGD (0.34) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL7983633 | 0.68 | POLB (0.34) | KEAP1NFE2L2C1S | |
| SCHEMBL5839757 | 0.67 | KEAP1 (0.41) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL6921023 | 0.66 | CSNK2A2 (0.38) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL6923952 | 0.64 | KEAP1 (0.41) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL7983631 | 0.64 | ALDH1A1 (0.33) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL6920646 | 0.64 | ALDH1A1 (0.40) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL6925163 | 0.63 | KEAP1 (0.47) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL6925497 | 0.63 | KEAP1 (0.41) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 | |
| SCHEMBL13738636 | 0.63 | KDM4E (0.42) | CSNK2A2KDRCSNK2BCSNK2A1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291514-B1 | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2001-09-18 | — | — | US | disclosed |