Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CDK4 | P11802 | 5/20 | 0.46 |
| ▸ | CCND1 | P24385 | 5/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 2/20 | 0.46 |
| ▸ | PRKACG | P22612 | 2/20 | 0.46 |
| ▸ | PRKACB | P22694 | 2/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.40 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982514 | 0.77 | GPR3 (0.46) | KDM4EMAPTCDK4CCND1NQO2 | |
| SCHEMBL7971139 | 0.74 | IDO1 (0.64) | KDM4EMAPTNQO2ALKBH5FTO | |
| SCHEMBL31634641 | 0.74 | IDO1 (0.64) | KDM4EMAPTNQO2ALKBH5FTO | |
| SCHEMBL29376819 | 0.73 | TERT (0.49) | KDM4EMAPTCDK4CCND1CCNE2 | |
| SCHEMBL31634605 | 0.72 | CYP1A2 (0.44) | KDM4EMAPTNQO2HSD17B10PARP1 | |
| SCHEMBL26214696 | 0.71 | KDM4E (0.64) | KDM4EMAPTCDK4CCND1CCNE2 | |
| SCHEMBL8156893 | 0.70 | KDM4E (0.41) | KDM4EMAPTCDK4CCND1CCNE2 | |
| SCHEMBL21793460 | 0.70 | KDM4E (1.00) | KDM4EMAPTCDK4CCND1CCNE2 | |
| SCHEMBL8112462 | 0.69 | GABRP (0.53) | KDM4EMAPTCDK4CCND1PRKACA | |
| SCHEMBL31634637 | 0.69 | TTR (0.44) | KDM4EMAPTHSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300340-B1 | USEFUL FOR THERAPY OF CANCER AND SOLID TUMORS | ADIR ET COMPAGNIE (FR) | 2001-10-09 | — | — | US | disclosed |
| US-6162822-A | Bisimide compounds | ADIR ET COMPAGNIE (FR) | 2000-12-19 | — | — | US | disclosed |
| EP-0820985-B1 | Bis imide derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-08-30 | — | — | EP | disclosed |
| EP-0820985-A1 | Bis imide derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-01-28 | — | — | EP | disclosed |