Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10901306 | 0.81 | KMT2A (0.56) | FLT1FLT4KDRALDH1A1TDP1 | |
| SCHEMBL14880709 | 0.80 | CES2 (0.69) | ALDH1A1TDP1TSHRLMNAHTT | |
| SCHEMBL9422048 | 0.76 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRLMNAHTT | |
| SCHEMBL16395918 | 0.76 | TP53 (0.66) | ALDH1A1TSHRLMNAHTTCES2 | |
| SCHEMBL10902732 | 0.75 | MAPK1 (0.63) | ALDH1A1TDP1TSHRLMNAHTT | |
| SCHEMBL28668332 | 0.75 | SMN1; SMN2 (0.52) | FLT1FLT4KDRALDH1A1TSHR | |
| SCHEMBL8124408 | 0.75 | ALDH1A1 (0.55) | FLT1FLT4KDRALDH1A1TDP1 | |
| SCHEMBL27983482 | 0.74 | ALDH1A1 (0.71) | ALDH1A1TDP1TSHRLMNAHTT | |
| SCHEMBL11507878 | 0.73 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRLMNAHTT | |
| SCHEMBL14984180 | 0.73 | ALDH1A1 (0.68) | ALDH1A1TDP1TSHRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001053276-A1 | DIHYDROFOLATE REDUCTASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2001-07-26 | — | — | WO | disclosed |