Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 12/20 | 0.56 |
| ▸ | FNTA | P49354 | 1/20 | 0.53 |
| ▸ | FNTB | P49356 | 1/20 | 0.53 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6812607 | 0.88 | AR (0.63) | ARFNTAFNTBPGGT1BL3MBTL1 | |
| SCHEMBL21585883 | 0.80 | FNTA (0.53) | ARFNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL15869707 | 0.80 | L3MBTL1 (0.58) | L3MBTL1SLC6A4HTR2AKCNH2SLC6A2 | |
| SCHEMBL23830071 | 0.79 | AR (0.53) | ARFNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL5344907 | 0.79 | AR (0.52) | ARCYP19A1 | |
| SCHEMBL5345762 | 0.78 | AR (0.51) | ARFNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL6812604 | 0.77 | FNTA (0.47) | ARFNTAFNTBPGGT1BL3MBTL1 | |
| SCHEMBL28923889 | 0.76 | AR (0.68) | ARFNTAFNTBPGGT1BCYP19A1 | |
| SCHEMBL11862979 | 0.76 | L3MBTL1 (0.58) | L3MBTL1SLC6A4HTR2AKCNH2SLC6A2 | |
| SCHEMBL7075721 | 0.75 | AR (0.49) | ARFNTAFNTBPGGT1BCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297239-B1 | Inhibitors of prenyl-protein transferase | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| EP-1021188-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| WO-1999017777-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |