Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 12/20 | 0.42 |
| ▸ | HTR7 | P34969 | 10/20 | 0.42 |
| ▸ | HTR6 | P50406 | 9/20 | 0.42 |
| ▸ | HTR1A | P08908 | 8/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL798631 | 0.98 | DRD2 (0.46) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL15064224 | 0.86 | HTR6 (0.51) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL798019 | 0.85 | DRD2 (0.48) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL792885 | 0.84 | HTR6 (0.53) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL792965 | 0.83 | DRD2 (0.61) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL797823 | 0.82 | DRD2 (0.50) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL797688 | 0.81 | DRD2 (0.54) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL792568 | 0.81 | DRD2 (0.62) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL797842 | 0.79 | DRD2 (0.55) | DRD2DRD3DRD4ADRA1AHTR2A | |
| SCHEMBL792247 | 0.79 | HTR1A (0.54) | DRD2DRD3DRD4ADRA1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616440-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | Adamed sp. z o.o. (PL) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035123-A1 | ARYLOSULFONAMIDES FOR THE TREATMENT OF CNS DISEASES | ADAMED SP. Z O.O. (PL) | 2012-03-22 | — | — | WO | disclosed |