Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 1/20 | 0.51 |
| ▸ | PRKACG | P22612 | 1/20 | 0.51 |
| ▸ | PRKACB | P22694 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | EBP | Q15125 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970968 | 0.85 | TSHR (0.47) | SRCMAPTALDH1A1KMT2A | |
| SCHEMBL7984333 | 0.79 | MAPT (0.53) | SRCSIGMAR1EBPTMEM97MAPT | |
| SCHEMBL7981648 | 0.76 | SRC (0.53) | SRCPRKACAPRKACGPRKACBMAPT | |
| SCHEMBL7970472 | 0.76 | SRC (0.55) | SRCPRKACAPRKACGPRKACBMAPT | |
| SCHEMBL7983968 | 0.74 | SRC (0.56) | SRCPRKACAPRKACGPRKACBMAPT | |
| SCHEMBL7980441 | 0.73 | SRC (0.53) | SRCPRKACAPRKACGPRKACBMAPT | |
| SCHEMBL7403886 | 0.73 | ALDH1A1 (0.46) | SIGMAR1EBPTMEM97MAPTPDE4A | |
| SCHEMBL7983938 | 0.72 | SRC (0.50) | SRCMAPTALDH1A1GAAL3MBTL1 | |
| SCHEMBL9370571 | 0.72 | SRC (0.57) | SRCMAPTALDH1A1KMT2A | |
| SCHEMBL7980591 | 0.71 | TSHR (0.52) | SRCMAPTPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |