Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RORA | P35398 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | RORB | Q92753 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | EBP | Q15125 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7970086 | 0.84 | SRC (0.63) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7403886 | 0.81 | ALDH1A1 (0.46) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7983612 | 0.80 | SRC (0.70) | ALDH1A1RORARORCRORBSRC | |
| SCHEMBL7984408 | 0.79 | SRC (0.51) | MAPTALDH1A1EBPSIGMAR1TMEM97 | |
| SCHEMBL7980611 | 0.77 | SRC (0.60) | MAPTALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL9370571 | 0.74 | SRC (0.57) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL20547147 | 0.70 | ALDH1A1 (0.50) | MAPTALDH1A1HPGDTSHRPOLB | |
| SCHEMBL9788901 | 0.70 | GSK3A (0.51) | ALDH1A1SIGMAR1SMN1; SMN2MAPK8 | |
| SCHEMBL7983884 | 0.69 | SRC (0.67) | MAPTALDH1A1KDM4ETSHRSRC | |
| SCHEMBL7970469 | 0.69 | NOX4 (0.71) | MAPTALDH1A1TSHRSRCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194439-B1 | ANTICANCER AGENT | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0586608-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| WO-1992021660-A1 | TRICYCLIC POLYHYDROXYLIC TYROSINE KINASE INHIBITORS | PFIZER, INC. (US) | 1992-12-10 | — | — | WO | disclosed |